Expression of IGSF8 in cancer - Summary

CANCER ATLAS

Gene description

Immunoglobulin superfamily, member 8

Protein class

CD markers, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA011917

GENE INFORMATION
Gene name	IGSF8 (HGNC Symbol)
Synonyms	CD316, CD81P3, EWI2, PGRL
Description	Immunoglobulin superfamily, member 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	160091340 - 160098943
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162729 (version 83.38)
Entrez gene	93185
UniProt	Q969P0 (UniProt - Evidence at protein level)
neXtProt	NX_Q969P0
Antibodypedia	IGSF8 antibodies

PROTEIN BROWSER

IGSF8-001	IGSF8-002	IGSF8-003	IGSF8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGSF8-001 ENSP00000316664 ENST00000314485	Q969P0 [Direct mapping] Immunoglobulin superfamily member 8 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0007338 [single fertilization] GO:0007399 [nervous system development] GO:0007519 [skeletal muscle tissue development] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	613 aa 65 kDa	Yes	1
IGSF8-002 ENSP00000397464 ENST00000448417	C9J8Z4 [Direct mapping] Immunoglobulin superfamily member 8 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	301 aa 32.3 kDa	Yes	0
IGSF8-003 ENSP00000357065 ENST00000368086	Q969P0 [Direct mapping] Immunoglobulin superfamily member 8 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0007338 [single fertilization] GO:0007399 [nervous system development] GO:0007519 [skeletal muscle tissue development] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	613 aa 65 kDa	Yes	1
IGSF8-201 ENSP00000477565 ENST00000614243	Q969P0 [Direct mapping] Immunoglobulin superfamily member 8 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0007338 [single fertilization] GO:0007399 [nervous system development] GO:0007519 [skeletal muscle tissue development] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	613 aa 65 kDa	Yes	1