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PEA15

GENERAL INFORMATION

Gene name

 PEA15

Gene description

 Phosphoprotein enriched in astrocytes 15

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PEA15 (HGNC Symbol)

Synonyms

 HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED

Description

 Phosphoprotein enriched in astrocytes 15 (HGNC Symbol)

Entrez gene summary

 This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 q23.2

Chromosome location (bp)

 160205337 - 160215376

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162734 (version 83.38)

Entrez gene

 8682

UniProt

 Q15121 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15121

Antibodypedia

 PEA15 antibodies

PROTEIN BROWSER
PEA15-001
PEA15-002
PEA15-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PEA15-001
ENSP00000353660
ENST00000360472
Q15121 [Direct mapping]
Astrocytic phosphoprotein PEA-15
B1AKZ4 [Target identity:100%; Query identity:100%]
Phosphoprotein enriched in astrocytes 15, isoform CRA_a; cDNA, FLJ92023, Homo sapiens phosphoprotein enriched in astrocytes 15 (PEA15),mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0006810 [transport]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046325 [negative regulation of glucose import]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 130 aa
15 kDa 		No 0
PEA15-002
ENSP00000357055
ENST00000368076
Q15121 [Direct mapping]
Astrocytic phosphoprotein PEA-15
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0006810 [transport]
GO:0006915 [apoptotic process]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008643 [carbohydrate transport]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043278 [response to morphine]
GO:0045087 [innate immune response]
GO:0046325 [negative regulation of glucose import]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 151 aa
17.3 kDa 		No 0
PEA15-003
ENSP00000357056
ENST00000368077
B1AKZ5 [Direct mapping]
Astrocytic phosphoprotein PEA-15
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0005515 [protein binding]
GO:0042981 [regulation of apoptotic process]
Show all
 108 aa
12.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.