Cell atlas - PEX19 - The Human Protein Atlas

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PEX19

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Peroxisomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	PEX19
Gene description	Peroxisomal biogenesis factor 19
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the peroxisome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Peroxisomes (validated)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA051966
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the peroxisome.

Main location

Peroxisomes (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051966	HEK 293	Peroxisomes
	HPA051966	HeLa	Nucleoplasm
	HPA051966	HeLa	Peroxisomes
	HPA051966	U-2 OS	Peroxisomes

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA051966	U-2 OS	Image	PEX19 localizes to peroxisomes, as it co-localizes with the peroxisomal marker ABCD3.

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000003464 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051966	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	PEX19 (HGNC Symbol)
Synonyms	D1S2223E, HK33, PMP1, PMPI, PXF, PXMP1
Description	Peroxisomal biogenesis factor 19 (HGNC Symbol)
Entrez gene summary	This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	q23.2
Chromosome location (bp)	160276812 - 160286348
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162735 (version 83.38)
Entrez gene	5824
UniProt	P40855 (UniProt - Evidence at protein level)
neXtProt	NX_P40855
Antibodypedia	PEX19 antibodies

PROTEIN BROWSER

PEX19-001	PEX19-003	PEX19-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX19-001 ENSP00000357051 ENST00000368072	P40855 [Direct mapping] Peroxisomal biogenesis factor 19 Show all	Transporters Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005829 [cytosol] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0016021 [integral component of membrane] GO:0016557 [peroxisome membrane biogenesis] GO:0016559 [peroxisome fission] GO:0031526 [brush border membrane] GO:0036105 [peroxisome membrane class-1 targeting sequence binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0045046 [protein import into peroxisome membrane] GO:0047485 [protein N-terminus binding] GO:0050821 [protein stabilization] GO:0051117 [ATPase binding] GO:0055085 [transmembrane transport] GO:0061077 [chaperone-mediated protein folding] GO:0072321 [chaperone-mediated protein transport] GO:0072663 [establishment of protein localization to peroxisome] GO:1900131 [negative regulation of lipid binding] Show all	299 aa 32.8 kDa	No	0
PEX19-003 ENSP00000376054 ENST00000392220	Q5QNY5 [Direct mapping] Peroxisomal biogenesis factor 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0043231 [intracellular membrane-bounded organelle] Show all	235 aa 26.1 kDa	No	0
PEX19-005 ENSP00000434567 ENST00000495624	H0YDY4 [Direct mapping] Peroxisomal biogenesis factor 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] Show all	119 aa 13.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.