Expression of LMX1A in cancer - Summary

CANCER ATLAS

Gene description

LIM homeobox transcription factor 1, alpha

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028051	HPA030088

GENE INFORMATION
Gene name	LMX1A (HGNC Symbol)
Synonyms	LMX1, LMX1.1
Description	LIM homeobox transcription factor 1, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	165201867 - 165356715
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162761 (version 83.38)
Entrez gene	4009
UniProt	Q8TE12 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TE12
Antibodypedia	LMX1A antibodies

PROTEIN BROWSER

LMX1A-001	LMX1A-002	LMX1A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMX1A-001 ENSP00000340226 ENST00000342310	Q8TE12 [Direct mapping] LIM homeobox transcription factor 1-alpha Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001558 [regulation of cell growth] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0008270 [zinc ion binding] GO:0010468 [regulation of gene expression] GO:0021542 [dentate gyrus development] GO:0021549 [cerebellum development] GO:0021766 [hippocampus development] GO:0021953 [central nervous system neuron differentiation] GO:0030182 [neuron differentiation] GO:0030901 [midbrain development] GO:0043565 [sequence-specific DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0071542 [dopaminergic neuron differentiation] Show all	382 aa 42.7 kDa	No	0
LMX1A-002 ENSP00000294816 ENST00000294816	Q8TE12 [Direct mapping] LIM homeobox transcription factor 1-alpha Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] Show all	382 aa 42.7 kDa	No	0
LMX1A-003 ENSP00000356868 ENST00000367893	Q8TE12 [Direct mapping] LIM homeobox transcription factor 1-alpha Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] Show all	382 aa 42.7 kDa	No	0