Cell atlas - KLHDC8A - The Human Protein Atlas

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KLHDC8A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	KLHDC8A
Gene description	Kelch domain containing 8A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (SCLC-21H, AF22, NTERA-2)
Protein evidence	Evidence at transcript level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, AF22, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	KLHDC8A (HGNC Symbol)
Synonyms	FLJ10748
Description	Kelch domain containing 8A (HGNC Symbol)
Entrez gene summary	This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	205336065 - 205357090
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000162873 (version 83.38)
Entrez gene	55220
UniProt	Q8IYD2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IYD2
Antibodypedia	KLHDC8A antibodies

PROTEIN BROWSER

KLHDC8A-001	KLHDC8A-002	KLHDC8A-003	KLHDC8A-004	KLHDC8A-005	KLHDC8A-007	KLHDC8A-008	KLHDC8A-009	KLHDC8A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHDC8A-001 ENSP00000356123 ENST00000367155	Q8IYD2 [Direct mapping] Kelch domain-containing protein 8A A0A024R981 [Target identity:100%; Query identity:100%] Kelch domain containing 8A, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	350 aa 38.9 kDa	No	0
KLHDC8A-002 ENSP00000356124 ENST00000367156	Q8IYD2 [Direct mapping] Kelch domain-containing protein 8A A0A024R981 [Target identity:100%; Query identity:100%] Kelch domain containing 8A, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	350 aa 38.9 kDa	No	0
KLHDC8A-003 ENSP00000475334 ENST00000491471	U3KPX9 [Direct mapping] Kelch domain-containing protein 8A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	66 aa 7.4 kDa	No	0
KLHDC8A-004 ENSP00000475871 ENST00000460687	U3KQH1 [Direct mapping] Kelch domain-containing protein 8A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	216 aa 24.2 kDa	No	0
KLHDC8A-005 ENSP00000475955 ENST00000606887	U3KQK4 [Direct mapping] Kelch domain-containing protein 8A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	26 aa 3.1 kDa	No	0
KLHDC8A-007 ENSP00000475902 ENST00000607826	U3KQI4 [Direct mapping] Kelch domain-containing protein 8A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	83 aa 9.2 kDa	No	0
KLHDC8A-008 ENSP00000475290 ENST00000607173	U3KPW1 [Direct mapping] Kelch domain-containing protein 8A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	79 aa 8.6 kDa	No	0
KLHDC8A-009 ENSP00000475745 ENST00000606181	U3KQC2 [Direct mapping] Kelch domain-containing protein 8A Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	176 aa 20.2 kDa	No	0
KLHDC8A-201 ENSP00000442229 ENST00000539253	Q8IYD2 [Direct mapping] Kelch domain-containing protein 8A A0A024R981 [Target identity:100%; Query identity:100%] Kelch domain containing 8A, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	350 aa 38.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.