Expression of HAAO in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

3-hydroxyanthranilate 3,4-dioxygenase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036394	HPA042024

GENE INFORMATION
Gene name	HAAO
Synonyms
Description	3-hydroxyanthranilate 3,4-dioxygenase (HGNC Symbol)
Entrez gene summary	3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p21
Chromosome location (bp)	42767089 - 42792593
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000162882 (version 83.38)
Entrez gene	23498
UniProt	P46952 (UniProt - Evidence at protein level)
neXtProt	NX_P46952
Antibodypedia	HAAO antibodies

PROTEIN BROWSER

HAAO-001	HAAO-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAAO-001 ENSP00000294973 ENST00000294973	P46952 [Direct mapping] 3-hydroxyanthranilate 3,4-dioxygenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000334 [3-hydroxyanthranilate 3,4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006569 [tryptophan catabolic process] GO:0008198 [ferrous iron binding] GO:0009055 [electron carrier activity] GO:0010043 [response to zinc ion] GO:0019805 [quinolinate biosynthetic process] GO:0034354 ['de novo' NAD biosynthetic process from tryptophan] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043420 [anthranilate metabolic process] GO:0044281 [small molecule metabolic process] GO:0046686 [response to cadmium ion] GO:0046872 [metal ion binding] GO:0046874 [quinolinate metabolic process] GO:0055114 [oxidation-reduction process] GO:0070050 [neuron cellular homeostasis] GO:0070062 [extracellular exosome] Show all	286 aa 32.6 kDa	No	0
HAAO-004 ENSP00000412601 ENST00000431905	C9IY88 [Direct mapping] 3-hydroxyanthranilate 3,4-dioxygenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000334 [3-hydroxyanthranilate 3,4-dioxygenase activity] GO:0005506 [iron ion binding] GO:0055114 [oxidation-reduction process] Show all	177 aa 20.5 kDa	No	0