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A majority of cancer tissues showed weak to moderate cytoplasmic positivity with additional membranous staining in a few cases. Gliomas and lymphomas were generally negative.
GENE INFORMATION
Gene name
ARL5A (HGNC Symbol)
Synonyms
ARL5
Description
ADP-ribosylation factor-like 5A (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]