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FRZB

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GENERAL INFORMATION

Gene name

 FRZB

Gene description

 Frizzled-related protein

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (AF22, NTERA-2, SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, NTERA-2, SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 FRZB (HGNC Symbol)

Synonyms

 FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, hFIZ, SFRP3, SRFP3

Description

 Frizzled-related protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

Chromosome

 2

Cytoband

 q32.1

Chromosome location (bp)

 182833275 - 182867162

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162998 (version 83.38)

Entrez gene

 2487

UniProt

 Q92765 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92765

Antibodypedia

 FRZB antibodies

PROTEIN BROWSER
FRZB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FRZB-001
ENSP00000295113
ENST00000295113
Q92765 [Direct mapping]
Secreted frizzled-related protein 3
D9ZGF6 [Target identity:100%; Query identity:100%]
Frizzled-related protein
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0008285 [negative regulation of cell proliferation]
GO:0010721 [negative regulation of cell development]
GO:0014033 [neural crest cell differentiation]
GO:0016020 [membrane]
GO:0017147 [Wnt-protein binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030308 [negative regulation of cell growth]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042472 [inner ear morphogenesis]
GO:0043065 [positive regulation of apoptotic process]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0060029 [convergent extension involved in organogenesis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0061037 [negative regulation of cartilage development]
GO:0061053 [somite development]
GO:0070367 [negative regulation of hepatocyte differentiation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090103 [cochlea morphogenesis]
Show all
 325 aa
36.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.