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DUSP19

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GENERAL INFORMATION

Gene name

 DUSP19

Gene description

 Dual specificity phosphatase 19

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA021501
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA021501 SK-MEL-30 Nucleoplasm
Nuclear speckles Intensity
HPA021501 U-2 OS Nucleoplasm
HPA021501 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 DUSP19 (HGNC Symbol)

Synonyms

 DUSP17, SKRP1

Description

 Dual specificity phosphatase 19 (HGNC Symbol)

Entrez gene summary

 Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Chromosome

 2

Cytoband

 q32.1

Chromosome location (bp)

 183078559 - 183100005

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000162999 (version 83.38)

Entrez gene

 142679

UniProt

 Q8WTR2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WTR2

Antibodypedia

 DUSP19 antibodies

PROTEIN BROWSER
DUSP19-001
DUSP19-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP19-001
ENSP00000346160
ENST00000354221
Q8WTR2 [Direct mapping]
Dual specificity protein phosphatase 19
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000188 [inactivation of MAPK activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005078 [MAP-kinase scaffold activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006470 [protein dephosphorylation]
GO:0007254 [JNK cascade]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008330 [protein tyrosine/threonine phosphatase activity]
GO:0008579 [JUN kinase phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030295 [protein kinase activator activity]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046329 [negative regulation of JNK cascade]
GO:0046330 [positive regulation of JNK cascade]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 217 aa
24.2 kDa 		No 0
DUSP19-002
ENSP00000343905
ENST00000342619
Q8WTR2 [Direct mapping]
Dual specificity protein phosphatase 19
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005078 [MAP-kinase scaffold activity]
GO:0005515 [protein binding]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006470 [protein dephosphorylation]
GO:0007254 [JNK cascade]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008579 [JUN kinase phosphatase activity]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030295 [protein kinase activator activity]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032147 [activation of protein kinase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043508 [negative regulation of JUN kinase activity]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046329 [negative regulation of JNK cascade]
GO:0046330 [positive regulation of JNK cascade]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 166 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.