Cell atlas - SGCB - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SGCB

premium

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	SGCB
Gene description	Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058656
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058656	A-431	Cytosol	Intensity
	HPA058656	U-2 OS	Cytosol	Intensity
	HPA058656	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SGCB (HGNC Symbol)
Synonyms	A3b, LGMD2E, SGC
Description	Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	52020706 - 52038482
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163069 (version 83.38)
Entrez gene	6443
UniProt	Q16585 (UniProt - Evidence at protein level)
neXtProt	NX_Q16585
Antibodypedia	SGCB antibodies

PROTEIN BROWSER

SGCB-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SGCB-001 ENSP00000370839 ENST00000381431	Q16585 [Direct mapping] Beta-sarcoglycan Q5U0N0 [Target identity:100%; Query identity:100%] Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein); Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein), isoform CRA_a; cDNA FLJ75413, highly similar to Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005887 [integral component of plasma membrane] GO:0007517 [muscle organ development] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016011 [dystroglycan complex] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0048747 [muscle fiber development] GO:0055013 [cardiac muscle cell development] GO:0097084 [vascular smooth muscle cell development] Show all	318 aa 34.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.