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PDLIM5

GENERAL INFORMATION

Gene name

 PDLIM5

Gene description

 PDZ and LIM domain 5

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membrane expression in several tissues, most abundant in myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA016740 , HPA020026 , CAB013511
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDLIM5 (HGNC Symbol)

Synonyms

 Enh, LIM

Description

 PDZ and LIM domain 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Chromosome

 4

Cytoband

 q22.3

Chromosome location (bp)

 94451857 - 94668227

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163110 (version 83.38)

Entrez gene

 10611

UniProt

 Q96HC4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96HC4

Antibodypedia

 PDLIM5 antibodies

PROTEIN BROWSER
«
PDLIM5-001
PDLIM5-002
PDLIM5-003
PDLIM5-004
PDLIM5-005
PDLIM5-008
PDLIM5-010
PDLIM5-013
PDLIM5-016
PDLIM5-020
PDLIM5-201
PDLIM5-202
PDLIM5-203
PDLIM5-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDLIM5-001
ENSP00000321746
ENST00000317968
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 596 aa
63.9 kDa 		No 0
PDLIM5-002
ENSP00000426379
ENST00000512274
D6RGG6 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 47 aa
5.3 kDa 		No 0
PDLIM5-003
ENSP00000423009
ENST00000504489
D6RAA1 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 38 aa
4.3 kDa 		No 0
PDLIM5-004
ENSP00000352210
ENST00000359265
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 136 aa
15.1 kDa 		No 1
PDLIM5-005
ENSP00000424297
ENST00000503974
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 483 aa
52.6 kDa 		No 0
PDLIM5-008
ENSP00000426804
ENST00000508216
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 234 aa
25.9 kDa 		No 0
PDLIM5-010
ENSP00000424360
ENST00000514743
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 625 aa
67.7 kDa 		No 0
PDLIM5-013
ENSP00000486834
ENST00000510099
A0A0D9SFR4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 177 aa
17.9 kDa 		No 0
PDLIM5-016
ENSP00000429577
ENST00000513341
H0YBI4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 196 aa
21.7 kDa 		No 0
PDLIM5-020
ENSP00000442187
ENST00000542407
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 487 aa
53.1 kDa 		No 0
PDLIM5-201
ENSP00000322021
ENST00000318007
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 214 aa
23.8 kDa 		No 0
PDLIM5-202
ENSP00000369527
ENST00000380180
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 234 aa
25.9 kDa 		No 0
PDLIM5-203
ENSP00000398469
ENST00000437932
A0A0A0MSP3 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 271 aa
29.7 kDa 		No 0
PDLIM5-204
ENSP00000480359
ENST00000615540
Q96HC4 [Direct mapping]
PDZ and LIM domain protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030018 [Z disc]
GO:0030054 [cell junction]
GO:0042805 [actinin binding]
GO:0043005 [neuron projection]
GO:0045211 [postsynaptic membrane]
GO:0047485 [protein N-terminus binding]
GO:0051963 [regulation of synapse assembly]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0061049 [cell growth involved in cardiac muscle cell development]
Show all
 625 aa
67.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.