Expression of TGFA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Transforming growth factor, alpha

Protein class

Cancer-related genes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042297

GENE INFORMATION
Gene name	TGFA
Synonyms
Description	Transforming growth factor, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	70447280 - 70554193
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163235 (version 83.38)
Entrez gene	7039
UniProt	P01135 (UniProt - Evidence at protein level)
neXtProt	NX_P01135
Antibodypedia	TGFA antibodies

PROTEIN BROWSER

TGFA-001	TGFA-002	TGFA-003	TGFA-005	TGFA-006	TGFA-012	TGFA-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TGFA-001 ENSP00000295400 ENST00000295400	P01135 [Direct mapping] Protransforming growth factor alpha Transforming growth factor alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000187 [activation of MAPK activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016323 [basolateral plasma membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0031410 [cytoplasmic vesicle] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0048208 [COPII vesicle coating] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0061024 [membrane organization] Show all	160 aa 17 kDa	Yes	1
TGFA-002 ENSP00000404131 ENST00000444975	F8VNR3 [Direct mapping] Protransforming growth factor alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001525 [angiogenesis] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0042060 [wound healing] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0048523 [negative regulation of cellular process] GO:0060749 [mammary gland alveolus development] GO:0072574 [hepatocyte proliferation] Show all	166 aa 17.8 kDa	Yes	1
TGFA-003 ENSP00000414127 ENST00000450929	E7EPT6 [Direct mapping] Protransforming growth factor alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] Show all	165 aa 17.7 kDa	Yes	1
TGFA-005 ENSP00000387493 ENST00000445399	P01135 [Direct mapping] Protransforming growth factor alpha Transforming growth factor alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000139 [Golgi membrane] GO:0000187 [activation of MAPK activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016323 [basolateral plasma membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0031410 [cytoplasmic vesicle] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0048208 [COPII vesicle coating] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0061024 [membrane organization] Show all	161 aa 17.1 kDa	Yes	1
TGFA-006 ENSP00000407432 ENST00000419940	H0Y6S5 [Direct mapping] Protransforming growth factor alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] Show all	131 aa 14.2 kDa	No	1
TGFA-012 ENSP00000377787 ENST00000394241	F8WA74 [Direct mapping] Protransforming growth factor alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] Show all	120 aa 12.5 kDa	Yes	1
TGFA-016 ENSP00000404099 ENST00000418333	P01135 [Direct mapping] Protransforming growth factor alpha Transforming growth factor alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000187 [activation of MAPK activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016323 [basolateral plasma membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0031410 [cytoplasmic vesicle] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0048208 [COPII vesicle coating] GO:0048471 [perinuclear region of cytoplasm] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0061024 [membrane organization] Show all	159 aa 16.9 kDa	Yes	1