Fields »
ABOUT
HELP
BLOG
NPPC

GENERAL INFORMATION

Gene name

 NPPC

Gene description

 Natriuretic peptide C

Protein class

 Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (prostate)
GTEx:Mixed
FANTOM5:Tissue enhanced (epididymis, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA035362
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis, retina)

GENE INFORMATION

Gene name

 NPPC (HGNC Symbol)

Synonyms

 CNP

Description

 Natriuretic peptide C (HGNC Symbol)

Entrez gene summary

 This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 231921820 - 231926403

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163273 (version 83.38)

Entrez gene

 4880

UniProt

 P23582 (UniProt - Evidence at protein level)

neXtProt

 NX_P23582

Antibodypedia

 NPPC antibodies

PROTEIN BROWSER
NPPC-001
NPPC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPPC-001
ENSP00000295440
ENST00000295440
P23582 [Direct mapping]
C-type natriuretic peptide CNP-22 CNP-29 CNP-53
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001503 [ossification]
GO:0003418 [growth plate cartilage chondrocyte differentiation]
GO:0003419 [growth plate cartilage chondrocyte proliferation]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0006182 [cGMP biosynthetic process]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0030814 [regulation of cAMP metabolic process]
GO:0030823 [regulation of cGMP metabolic process]
GO:0050880 [regulation of blood vessel size]
GO:0051447 [negative regulation of meiotic cell cycle]
GO:1900194 [negative regulation of oocyte maturation]
Show all
 126 aa
13.2 kDa 		Yes 0
NPPC-002
ENSP00000387159
ENST00000409852
P23582 [Direct mapping]
C-type natriuretic peptide CNP-22 CNP-29 CNP-53
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001503 [ossification]
GO:0001666 [response to hypoxia]
GO:0003418 [growth plate cartilage chondrocyte differentiation]
GO:0003419 [growth plate cartilage chondrocyte proliferation]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006182 [cGMP biosynthetic process]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0009791 [post-embryonic development]
GO:0030141 [secretory granule]
GO:0030814 [regulation of cAMP metabolic process]
GO:0030823 [regulation of cGMP metabolic process]
GO:0030828 [positive regulation of cGMP biosynthetic process]
GO:0040014 [regulation of multicellular organism growth]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0044702 [single organism reproductive process]
GO:0045471 [response to ethanol]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045909 [positive regulation of vasodilation]
GO:0048513 [organ development]
GO:0048660 [regulation of smooth muscle cell proliferation]
GO:0050880 [regulation of blood vessel size]
GO:0051053 [negative regulation of DNA metabolic process]
GO:0051428 [peptide hormone receptor binding]
GO:0051447 [negative regulation of meiotic cell cycle]
GO:1900194 [negative regulation of oocyte maturation]
Show all
 126 aa
13.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.