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GABRG1

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GENERAL INFORMATION

Gene name

 GABRG1

Gene description

 Gamma-aminobutyric acid (GABA) A receptor, gamma 1

Protein class

 FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-266/70)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GABRG1

Synonyms

Description

 Gamma-aminobutyric acid (GABA) A receptor, gamma 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p12

Chromosome location (bp)

 46035769 - 46124081

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000163285 (version 83.38)

Entrez gene

 2565

UniProt

 Q8N1C3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N1C3

Antibodypedia

 GABRG1 antibodies

PROTEIN BROWSER
GABRG1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GABRG1-001
ENSP00000295452
ENST00000295452
Q8N1C3 [Direct mapping]
Gamma-aminobutyric acid receptor subunit gamma-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004890 [GABA-A receptor activity]
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005237 [inhibitory extracellular ligand-gated ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008503 [benzodiazepine receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043235 [receptor complex]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050811 [GABA receptor binding]
GO:0050877 [neurological system process]
GO:1902476 [chloride transmembrane transport]
GO:1902711 [GABA-A receptor complex]
Show all
 465 aa
53.6 kDa 		Yes 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.