Cell atlas - ALPI - The Human Protein Atlas

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ALPI

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ALPI
Gene description	Alkaline phosphatase, intestinal
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038764
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038764	HeLa	Plasma membrane
	HPA038764	SiHa	No staining
	HPA038764	U-2 OS	No staining

GENE INFORMATION
Gene name	ALPI
Synonyms
Description	Alkaline phosphatase, intestinal (HGNC Symbol)
Entrez gene summary	There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	232456123 - 232460032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163295 (version 83.38)
Entrez gene	248
UniProt	P09923 (UniProt - Evidence at protein level)
neXtProt	NX_P09923
Antibodypedia	ALPI antibodies

PROTEIN BROWSER

ALPI-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALPI-001 ENSP00000295463 ENST00000295463	P09923 [Direct mapping] Intestinal-type alkaline phosphatase A0A024R4A2 [Target identity:100%; Query identity:100%] Alkaline phosphatase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0002020 [protease binding] GO:0003824 [catalytic activity] GO:0004035 [alkaline phosphatase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0031225 [anchored component of membrane] Show all	528 aa 56.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.