Cell atlas - CGGBP1 - The Human Protein Atlas

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CGGBP1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CGGBP1
Gene description	CGG triplet repeat binding protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA035568 , HPA037017
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035568	A-431	Nucleoplasm
	HPA035568	U-2 OS	Nucleoplasm
	HPA035568	U-251 MG	Nucleoplasm
	HPA037017	RH-30	Nucleus
	HPA037017	U-2 OS	No staining
	HPA037017	U-251 MG	Nucleus

GENE INFORMATION
Gene name	CGGBP1 (HGNC Symbol)
Synonyms	CGGBP, p20-CGGBP
Description	CGG triplet repeat binding protein 1 (HGNC Symbol)
Entrez gene summary	CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM, Mar 2008]
Chromosome	3
Cytoband	p11.1
Chromosome location (bp)	88051944 - 88149885
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163320 (version 83.38)
Entrez gene	8545
UniProt	Q9UFW8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UFW8
Antibodypedia	CGGBP1 antibodies

PROTEIN BROWSER

CGGBP1-001	CGGBP1-002	CGGBP1-003	CGGBP1-004	CGGBP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CGGBP1-001 ENSP00000381428 ENST00000309534	Q9UFW8 [Direct mapping] CGG triplet repeat-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] Show all	167 aa 18.8 kDa	No	0
CGGBP1-002 ENSP00000420374 ENST00000482016	Q9UFW8 [Direct mapping] CGG triplet repeat-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] Show all	167 aa 18.8 kDa	No	0
CGGBP1-003 ENSP00000381429 ENST00000398392	Q9UFW8 [Direct mapping] CGG triplet repeat-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] Show all	167 aa 18.8 kDa	No	0
CGGBP1-004 ENSP00000418769 ENST00000462901	Q9UFW8 [Direct mapping] CGG triplet repeat-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] Show all	167 aa 18.8 kDa	No	0
CGGBP1-005 ENSP00000419459 ENST00000467332	C9JUJ0 [Direct mapping] CGG triplet repeat-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] Show all	106 aa 11.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.