Cell atlas - EOGT - The Human Protein Atlas

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EOGT

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear membrane
	Nucleoplasm

Human cell
	Cytosol
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	EOGT
Gene description	EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane & nucleoplasm. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear membrane (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA019460
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane & nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved), Nuclear membrane (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA019460	A-431	Nucleoplasm
	HPA019460	A-431	Nuclear membrane
	HPA019460	U-2 OS	Nucleoplasm
			Nuclear membrane
			Cytosol
	HPA019460	U-251 MG	Nucleus
	HPA019460	U-251 MG	Cytosol

GENE INFORMATION
Gene name	EOGT (HGNC Symbol)
Synonyms	AER61, C3orf64, FLJ33770
Description	EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Chromosome	3
Cytoband	p14.1
Chromosome location (bp)	68975214 - 69013961
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163378 (version 83.38)
Entrez gene	285203
UniProt	Q5NDL2 (UniProt - Evidence at protein level)
neXtProt	NX_Q5NDL2
Antibodypedia	EOGT antibodies

PROTEIN BROWSER

EOGT-002	EOGT-003	EOGT-006	EOGT-007	EOGT-201	EOGT-202	EOGT-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EOGT-002 ENSP00000373206 ENST00000383701	Q5NDL2 [Direct mapping] EGF domain-specific O-linked N-acetylglucosamine transferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0008152 [metabolic process] GO:0016262 [protein N-acetylglucosaminyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	527 aa 62 kDa	Yes	0
EOGT-003 ENSP00000295571 ENST00000295571	Q5NDL2 [Direct mapping] EGF domain-specific O-linked N-acetylglucosamine transferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0016262 [protein N-acetylglucosaminyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	443 aa 52.3 kDa	Yes	0
EOGT-006 ENSP00000411832 ENST00000456376	C9J4G5 [Direct mapping] EGF domain-specific O-linked N-acetylglucosamine transferase; HCG1777404, isoform CRA_a; HCG1777404, isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 14.5 kDa	Yes	0
EOGT-007 ENSP00000408090 ENST00000424374	C9JQM7 [Direct mapping] EGF domain-specific O-linked N-acetylglucosamine transferase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 15.5 kDa	Yes	0
EOGT-201 ENSP00000443780 ENST00000540764	Q5NDL2 [Direct mapping] EGF domain-specific O-linked N-acetylglucosamine transferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0016262 [protein N-acetylglucosaminyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	527 aa 62 kDa	Yes	0
EOGT-202 ENSP00000444264 ENST00000540955	Q5NDL2 [Direct mapping] EGF domain-specific O-linked N-acetylglucosamine transferase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0016262 [protein N-acetylglucosaminyltransferase activity] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	443 aa 52.3 kDa	Yes	0
EOGT-203 ENSP00000480083 ENST00000615922	Q8N329 [Direct mapping] C3orf64 protein; EGF domain-specific O-linked N-acetylglucosamine transferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	135 aa 15.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.