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IGFBP7

GENERAL INFORMATION

Gene name

 IGFBP7

Gene description

 Insulin-like growth factor binding protein 7

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Plasma positivity in several tissues. Cytoplasmic expression mainly in pancreatic islet cells, renal tubules and Leydig cells.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA002196 , CAB020668
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IGFBP7 (HGNC Symbol)

Synonyms

 FSTL2, IGFBP-7, MAC25, PSF

Description

 Insulin-like growth factor binding protein 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 57030773 - 57110385

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163453 (version 83.38)

Entrez gene

 3490

UniProt

 Q16270 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16270

Antibodypedia

 IGFBP7 antibodies

PROTEIN BROWSER
IGFBP7-001
IGFBP7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGFBP7-001
ENSP00000295666
ENST00000295666
Q16270 [Direct mapping]
Insulin-like growth factor-binding protein 7
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0008285 [negative regulation of cell proliferation]
GO:0031012 [extracellular matrix]
GO:0048839 [inner ear development]
GO:0070062 [extracellular exosome]
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 282 aa
29.1 kDa 		Yes 0
IGFBP7-003
ENSP00000486293
ENST00000514062
Q16270 [Direct mapping]
Insulin-like growth factor-binding protein 7
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0008285 [negative regulation of cell proliferation]
GO:0031012 [extracellular matrix]
GO:0070062 [extracellular exosome]
Show all
 279 aa
28.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.