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CCT3

CANCER ATLAS

Gene description

 Chaperonin containing TCP1, subunit 3 (gamma)

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006543

GENE INFORMATION

Gene name

 CCT3 (HGNC Symbol)

Synonyms

 Cctg, TRIC5

Description

 Chaperonin containing TCP1, subunit 3 (gamma) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 156308968 - 156367873

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163468 (version 83.38)

Entrez gene

 7203

UniProt

 P49368 (UniProt - Evidence at protein level)

neXtProt

 NX_P49368

Antibodypedia

 CCT3 antibodies

PROTEIN BROWSER
CCT3-001
CCT3-004
CCT3-011
CCT3-013
CCT3-014
CCT3-017
CCT3-019
CCT3-020
CCT3-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCT3-001
ENSP00000295688
ENST00000295688
P49368 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002199 [zona pellucida receptor complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0007339 [binding of sperm to zona pellucida]
GO:0043209 [myelin sheath]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0046931 [pore complex assembly]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
GO:1901998 [toxin transport]
Show all
 545 aa
60.5 kDa 		No 0
CCT3-004
ENSP00000431543
ENST00000472765
B4DUR8 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 500 aa
55.7 kDa 		No 0
CCT3-011
ENSP00000413431
ENST00000415548
Q5SZX9 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 161 aa
17.5 kDa 		No 0
CCT3-013
ENSP00000388799
ENST00000446905
Q5SZW8 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 188 aa
20.9 kDa 		No 0
CCT3-014
ENSP00000413308
ENST00000413555
Q5SZX6 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 276 aa
30.8 kDa 		No 0
CCT3-017
ENSP00000357242
ENST00000368259
P49368 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
Show all
 507 aa
56.4 kDa 		No 0
CCT3-019
ENSP00000435026
ENST00000478640
E9PM09 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 154 aa
16.9 kDa 		No 0
CCT3-020
ENSP00000434481
ENST00000533194
E9PQ35 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 144 aa
16 kDa 		No 0
CCT3-021
ENSP00000434232
ENST00000496684
E9PRC8 [Direct mapping]
T-complex protein 1 subunit gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 234 aa
26 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.