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IHH

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GENERAL INFORMATION

Gene name

 IHH

Gene description

 Indian hedgehog

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (CACO-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (CACO-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 IHH (HGNC Symbol)

Synonyms

 BDA1, HHG2

Description

 Indian hedgehog (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 219054420 - 219060467

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163501 (version 83.38)

Entrez gene

 3549

UniProt

 Q14623 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14623

Antibodypedia

 IHH antibodies

PROTEIN BROWSER
IHH-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IHH-001
ENSP00000295731
ENST00000295731
Q14623 [Direct mapping]
Indian hedgehog protein Indian hedgehog protein N-product Indian hedgehog protein C-product
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001569 [patterning of blood vessels]
GO:0001649 [osteoblast differentiation]
GO:0001701 [in utero embryonic development]
GO:0001708 [cell fate specification]
GO:0001763 [morphogenesis of a branching structure]
GO:0001944 [vasculature development]
GO:0001947 [heart looping]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0003382 [epithelial cell morphogenesis]
GO:0003406 [retinal pigment epithelium development]
GO:0005113 [patched binding]
GO:0005509 [calcium ion binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006029 [proteoglycan metabolic process]
GO:0006508 [proteolysis]
GO:0007154 [cell communication]
GO:0007224 [smoothened signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organismal development]
GO:0007389 [pattern specification process]
GO:0008233 [peptidase activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0009880 [embryonic pattern specification]
GO:0009968 [negative regulation of signal transduction]
GO:0016539 [intein-mediated protein splicing]
GO:0030154 [cell differentiation]
GO:0030704 [vitelline membrane formation]
GO:0031016 [pancreas development]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0032355 [response to estradiol]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0033085 [negative regulation of T cell differentiation in thymus]
GO:0033088 [negative regulation of immature T cell proliferation in thymus]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0035264 [multicellular organism growth]
GO:0035988 [chondrocyte proliferation]
GO:0040008 [regulation of growth]
GO:0042733 [embryonic digit morphogenesis]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0045453 [bone resorption]
GO:0045595 [regulation of cell differentiation]
GO:0045596 [negative regulation of cell differentiation]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046638 [positive regulation of alpha-beta T cell differentiation]
GO:0046639 [negative regulation of alpha-beta T cell differentiation]
GO:0048074 [negative regulation of eye pigmentation]
GO:0048469 [cell maturation]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048666 [neuron development]
GO:0048745 [smooth muscle tissue development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051216 [cartilage development]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060220 [camera-type eye photoreceptor cell fate commitment]
GO:0060323 [head morphogenesis]
GO:0061053 [somite development]
GO:0072498 [embryonic skeletal joint development]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 411 aa
45.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.