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EOMES

GENERAL INFORMATION

Gene name

 EOMES

Gene description

 Eomesodermin

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen, lymph node)
GTEx:Group enriched (cerebellum, spleen)
FANTOM5:Tissue enhanced (spleen, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA028896
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, cerebellum)

GENE INFORMATION

Gene name

 EOMES (HGNC Symbol)

Synonyms

 TBR2

Description

 Eomesodermin (HGNC Symbol)

Entrez gene summary

 This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

 3

Cytoband

 p24.1

Chromosome location (bp)

 27715949 - 27722711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163508 (version 83.38)

Entrez gene

 8320

UniProt

 O95936 (UniProt - Evidence at protein level)

neXtProt

 NX_O95936

Antibodypedia

 EOMES antibodies

PROTEIN BROWSER
EOMES-001
EOMES-002
EOMES-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EOMES-001
ENSP00000295743
ENST00000295743
O95936 [Direct mapping]
Eomesodermin homolog
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0001706 [endoderm formation]
GO:0001707 [mesoderm formation]
GO:0002250 [adaptive immune response]
GO:0002302 [CD8-positive, alpha-beta T cell differentiation involved in immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0060809 [mesodermal to mesenchymal transition involved in gastrulation]
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 686 aa
72.7 kDa 		No 0
EOMES-002
ENSP00000388620
ENST00000449599
O95936 [Direct mapping]
Eomesodermin homolog
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0001706 [endoderm formation]
GO:0001707 [mesoderm formation]
GO:0001714 [endodermal cell fate specification]
GO:0001824 [blastocyst development]
GO:0001829 [trophectodermal cell differentiation]
GO:0002250 [adaptive immune response]
GO:0002302 [CD8-positive, alpha-beta T cell differentiation involved in immune response]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007420 [brain development]
GO:0010002 [cardioblast differentiation]
GO:0010468 [regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0021772 [olfactory bulb development]
GO:0021796 [cerebral cortex regionalization]
GO:0021895 [cerebral cortex neuron differentiation]
GO:0030154 [cell differentiation]
GO:0032609 [interferon-gamma production]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045664 [regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050767 [regulation of neurogenesis]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0060809 [mesodermal to mesenchymal transition involved in gastrulation]
Show all
 705 aa
74.9 kDa 		No 0
EOMES-004
ENSP00000487112
ENST00000461503
O95936 [Direct mapping]
Eomesodermin homolog
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0001706 [endoderm formation]
GO:0001707 [mesoderm formation]
GO:0002250 [adaptive immune response]
GO:0002302 [CD8-positive, alpha-beta T cell differentiation involved in immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0060809 [mesodermal to mesenchymal transition involved in gastrulation]
Show all
 410 aa
46 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.