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Several hepatocellular carcinomas along with a few prostate cancers showed weak to moderate nuclear staining while cytoplasmic positivity was seen in malignant gliomas. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
FCRL4 (HGNC Symbol)
Synonyms
CD307d, FCRH4, IGFP2, IRTA1
Description
Fc receptor-like 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
