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FBLN2

GENERAL INFORMATION

Gene name

 FBLN2

Gene description

 Fibulin 2

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in placental decidual cells and fibroblasts with distinct positivity in connective tissue.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA001934 , CAB018622
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 FBLN2

Synonyms

Description

 Fibulin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 13549131 - 13638422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163520 (version 83.38)

Entrez gene

 2199

UniProt

 P98095 (UniProt - Evidence at protein level)

neXtProt

 NX_P98095

Antibodypedia

 FBLN2 antibodies

PROTEIN BROWSER
FBLN2-001
FBLN2-002
FBLN2-004
FBLN2-006
FBLN2-007
FBLN2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBLN2-001
ENSP00000384169
ENST00000404922
P98095 [Direct mapping]
Fibulin-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0050840 [extracellular matrix binding]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 1231 aa
131.9 kDa 		Yes 0
FBLN2-002
ENSP00000295760
ENST00000295760
P98095 [Direct mapping]
Fibulin-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 1184 aa
126.6 kDa 		Yes 0
FBLN2-004
ENSP00000420164
ENST00000465610
C9JQS6 [Direct mapping]
Fibulin-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 159 aa
16.5 kDa 		Yes 0
FBLN2-006
ENSP00000295761
ENST00000295761
H7BXL0 [Direct mapping]
Fibulin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
 109 aa
11.7 kDa 		No 0
FBLN2-007
ENSP00000399224
ENST00000421373
H7C1A3 [Direct mapping]
Fibulin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 101 aa
11.5 kDa 		No 0
FBLN2-008
ENSP00000420042
ENST00000492059
P98095 [Direct mapping]
Fibulin-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 1231 aa
131.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.