Expression of CHCHD4 in cancer - Summary

CANCER ATLAS

Gene description

Coiled-coil-helix-coiled-coil-helix domain containing 4

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034688

GENE INFORMATION
Gene name	CHCHD4 (HGNC Symbol)
Synonyms	FLJ31709, MIA40, TIMM40
Description	Coiled-coil-helix-coiled-coil-helix domain containing 4 (HGNC Symbol)
Entrez gene summary	CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]
Chromosome	3
Cytoband	p25.1
Chromosome location (bp)	14112077 - 14124870
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163528 (version 83.38)
Entrez gene	131474
UniProt	Q8N4Q1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4Q1
Antibodypedia	CHCHD4 antibodies

PROTEIN BROWSER

CHCHD4-001	CHCHD4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHCHD4-001 ENSP00000380122 ENST00000396914	Q8N4Q1 [Direct mapping] Mitochondrial intermembrane space import and assembly protein 40 A0A024R2I5 [Target identity:100%; Query identity:100%] Coiled-coil-helix-coiled-coil-helix domain containing 4, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0006626 [protein targeting to mitochondrion] GO:0015035 [protein disulfide oxidoreductase activity] GO:0022417 [protein maturation by protein folding] GO:0044267 [cellular protein metabolic process] GO:0045041 [protein import into mitochondrial intermembrane space] GO:0051084 ['de novo' posttranslational protein folding] GO:0055114 [oxidation-reduction process] Show all	142 aa 16 kDa	No	0
CHCHD4-002 ENSP00000295767 ENST00000295767	Q8N4Q1 [Direct mapping] Mitochondrial intermembrane space import and assembly protein 40 A0A024R2F8 [Target identity:100%; Query identity:100%] Coiled-coil-helix-coiled-coil-helix domain containing 4, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0006626 [protein targeting to mitochondrion] GO:0015035 [protein disulfide oxidoreductase activity] GO:0022417 [protein maturation by protein folding] GO:0034599 [cellular response to oxidative stress] GO:0043504 [mitochondrial DNA repair] GO:0044267 [cellular protein metabolic process] GO:0045041 [protein import into mitochondrial intermembrane space] GO:0046825 [regulation of protein export from nucleus] GO:0051084 ['de novo' posttranslational protein folding] GO:0055114 [oxidation-reduction process] GO:0072655 [establishment of protein localization to mitochondrion] GO:1901857 [positive regulation of cellular respiration] Show all	155 aa 17.4 kDa	No	0