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Several cancers displayed weak to moderate cytoplasmic positivity while ovarian cancers showed moderate to strong staining. Gliomas, lymphomas, melanomas, renal and liver cancers were generally negative.
GENE INFORMATION
Gene name
PRKCI (HGNC Symbol)
Synonyms
DXS1179E, PKCI
Description
Protein kinase C, iota (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]