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SLC2A2

GENERAL INFORMATION

Gene name

 SLC2A2

Gene description

 Solute carrier family 2 (facilitated glucose transporter), member 2

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Group enriched (liver, small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Selective membranous expression in hepatocytes, small intestine and renal tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA028997 , CAB010444
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine, colon)

GENE INFORMATION

Gene name

 SLC2A2 (HGNC Symbol)

Synonyms

 GLUT2

Description

 Solute carrier family 2 (facilitated glucose transporter), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

 3

Cytoband

 q26.2

Chromosome location (bp)

 170996348 - 171026750

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163581 (version 83.38)

Entrez gene

 6514

UniProt

 P11168 (UniProt - Evidence at protein level)

neXtProt

 NX_P11168

Antibodypedia

 SLC2A2 antibodies

PROTEIN BROWSER
SLC2A2-001
SLC2A2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC2A2-001
ENSP00000323568
ENST00000314251
P11168 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 2
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005975 [carbohydrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008645 [hexose transport]
GO:0009749 [response to glucose]
GO:0009758 [carbohydrate utilization]
GO:0015149 [hexose transmembrane transporter activity]
GO:0015755 [fructose transport]
GO:0015758 [glucose transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022857 [transmembrane transporter activity]
GO:0022891 [substrate-specific transmembrane transporter activity]
GO:0031018 [endocrine pancreas development]
GO:0031526 [brush border membrane]
GO:0033300 [dehydroascorbic acid transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0043434 [response to peptide hormone]
GO:0044281 [small molecule metabolic process]
GO:0046323 [glucose import]
GO:0050796 [regulation of insulin secretion]
GO:0055056 [D-glucose transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0070837 [dehydroascorbic acid transport]
GO:1904659 [glucose transmembrane transport]
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 524 aa
57.5 kDa 		No >9
SLC2A2-007
ENSP00000418888
ENST00000461867
C9J0E8 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005351 [sugar:proton symporter activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
Show all
 103 aa
11.6 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.