Cell atlas - CTLA4 - The Human Protein Atlas

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CTLA4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CTLA4
Gene description	Cytotoxic T-lymphocyte-associated protein 4
Protein class	CD markers Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (U-266/84, U-266/70, SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-266/84, U-266/70, SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CTLA4 (HGNC Symbol)
Synonyms	CD, CD152, CD28, CELIAC3, GSE, ICOS, IDDM12
Description	Cytotoxic T-lymphocyte-associated protein 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q33.2
Chromosome location (bp)	203867786 - 203873960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163599 (version 83.38)
Entrez gene	1493
UniProt	P16410 (UniProt - Evidence at protein level)
neXtProt	NX_P16410
Antibodypedia	CTLA4 antibodies

PROTEIN BROWSER

CTLA4-001	CTLA4-002	CTLA4-004	CTLA4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTLA4-001 ENSP00000303939 ENST00000302823	P16410 [Direct mapping] Cytotoxic T-lymphocyte protein 4 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0006974 [cellular response to DNA damage stimulus] GO:0009897 [external side of plasma membrane] GO:0030889 [negative regulation of B cell proliferation] GO:0031295 [T cell costimulation] GO:0043065 [positive regulation of apoptotic process] GO:0045334 [clathrin-coated endocytic vesicle] GO:0045590 [negative regulation of regulatory T cell differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:0050853 [B cell receptor signaling pathway] Show all	223 aa 24.7 kDa	Yes	1
CTLA4-002 ENSP00000409707 ENST00000427473	A0A0C4DH58 [Direct mapping] Cytotoxic T-lymphocyte protein 4 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] Show all	137 aa 14.9 kDa	No	0
CTLA4-004 ENSP00000417779 ENST00000472206	P16410 [Direct mapping] Cytotoxic T-lymphocyte protein 4 Show all	CD markers MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0006974 [cellular response to DNA damage stimulus] GO:0009897 [external side of plasma membrane] GO:0030889 [negative regulation of B cell proliferation] GO:0031295 [T cell costimulation] GO:0043065 [positive regulation of apoptotic process] GO:0045334 [clathrin-coated endocytic vesicle] GO:0045590 [negative regulation of regulatory T cell differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:0050853 [B cell receptor signaling pathway] Show all	79 aa 8.9 kDa	Yes	0
CTLA4-005 ENSP00000295854 ENST00000295854	P16410 [Direct mapping] Cytotoxic T-lymphocyte protein 4 Show all	CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Biotech drugs Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0006974 [cellular response to DNA damage stimulus] GO:0009897 [external side of plasma membrane] GO:0030889 [negative regulation of B cell proliferation] GO:0031295 [T cell costimulation] GO:0043065 [positive regulation of apoptotic process] GO:0045334 [clathrin-coated endocytic vesicle] GO:0045590 [negative regulation of regulatory T cell differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:0050853 [B cell receptor signaling pathway] Show all	174 aa 19.1 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.