Cell atlas - HESX1 - The Human Protein Atlas

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HESX1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HESX1
Gene description	HESX homeobox 1
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enhanced (NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA024187
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024187	SH-SY5Y	Nucleus
	HPA024187	SK-MEL-30	Nucleoplasm
	HPA024187	U-2 OS	No staining

GENE INFORMATION
Gene name	HESX1 (HGNC Symbol)
Synonyms	ANF, RPX
Description	HESX homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	57197843 - 57226521
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163666 (version 83.38)
Entrez gene	8820
UniProt	Q9UBX0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBX0
Antibodypedia	HESX1 antibodies

PROTEIN BROWSER

HESX1-001	HESX1-002	HESX1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HESX1-001 ENSP00000295934 ENST00000295934	Q9UBX0 [Direct mapping] Homeobox expressed in ES cells 1 A0A024R364 [Target identity:100%; Query identity:100%] Homeobox, ES cell expressed 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007420 [brain development] GO:0008022 [protein C-terminus binding] GO:0030916 [otic vesicle formation] GO:0043565 [sequence-specific DNA binding] GO:0043584 [nose development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0048853 [forebrain morphogenesis] Show all	185 aa 21.4 kDa	No	0
HESX1-002 ENSP00000418918 ENST00000473921	C9J0A9 [Direct mapping] Homeobox-expressed in ES cells 1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	151 aa 17.4 kDa	No	0
HESX1-003 ENSP00000419615 ENST00000495160	J3KR67 [Direct mapping] Homeobox-expressed in ES cells 1 Show all	Predicted intracellular proteins Show all		107 aa 12 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.