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IL17RE

GENERAL INFORMATION

Gene name

 IL17RE

Gene description

 Interleukin 17 receptor E

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enhanced (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and/or nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA019011
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, colon)

GENE INFORMATION

Gene name

 IL17RE (HGNC Symbol)

Synonyms

 FLJ23658

Description

 Interleukin 17 receptor E (HGNC Symbol)

Entrez gene summary

 This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 9902612 - 9916402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163701 (version 83.38)

Entrez gene

 132014

UniProt

 Q8NFR9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFR9

Antibodypedia

 IL17RE antibodies

PROTEIN BROWSER
IL17RE-001
IL17RE-002
IL17RE-003
IL17RE-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL17RE-001
ENSP00000373325
ENST00000383814
Q8NFR9 [Direct mapping]
Interleukin-17 receptor E
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
Show all
 667 aa
74.8 kDa 		Yes 1
IL17RE-002
ENSP00000404916
ENST00000421412
J3KQN7 [Direct mapping]
Interleukin 17 receptor E, isoform CRA_c; Interleukin-17 receptor E
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005887 [integral component of plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
Show all
 700 aa
78.4 kDa 		Yes 1
IL17RE-003
ENSP00000388086
ENST00000454190
Q8NFR9 [Direct mapping]
Interleukin-17 receptor E
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
Show all
 533 aa
58.1 kDa 		Yes 0
IL17RE-010
ENSP00000400768
ENST00000454992
C9J1R2 [Direct mapping]
Interleukin-17 receptor E
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005887 [integral component of plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
Show all
 173 aa
19.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.