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A majority of cancers were negative. A few cases of melanomas, colorectal, skin, testicular and pancreatic cancers showed moderate to strong positivity.
Most cancer cells were weakly stained or negative. Most carcinoids, prostate and breast cancers, several endometrial, skin and thyroid cancers showed moderate cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
IL17RC (HGNC Symbol)
Synonyms
IL17-RL
Description
Interleukin 17 receptor C (HGNC Symbol)
Entrez gene summary
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
