Expression of CRELD1 in cancer - Summary

CANCER ATLAS

Gene description

Cysteine-rich with EGF-like domains 1

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026964

GENE INFORMATION
Gene name	CRELD1 (HGNC Symbol)
Synonyms	AVSD2
Description	Cysteine-rich with EGF-like domains 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9933822 - 9945413
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163703 (version 83.38)
Entrez gene	78987
UniProt	Q96HD1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96HD1
Antibodypedia	CRELD1 antibodies

PROTEIN BROWSER

CRELD1-001	CRELD1-002	CRELD1-003	CRELD1-004	CRELD1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRELD1-001 ENSP00000373322 ENST00000383811	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	420 aa 45.4 kDa	Yes	1
CRELD1-002 ENSP00000380355 ENST00000397170	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	420 aa 45.4 kDa	Yes	1
CRELD1-003 ENSP00000393643 ENST00000452070	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	420 aa 45.4 kDa	Yes	1
CRELD1-004 ENSP00000321856 ENST00000326434	Q96HD1 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	422 aa 45.9 kDa	Yes	0
CRELD1-013 ENSP00000406556 ENST00000435417	H7C2L3 [Direct mapping] Cysteine-rich with EGF-like domain protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	100 aa 10.6 kDa	No	0