Cell atlas - CPA3 - The Human Protein Atlas

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CPA3

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CPA3
Gene description	Carboxypeptidase A3 (mast cell)
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (HEL)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CPA3
Synonyms
Description	Carboxypeptidase A3 (mast cell) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]
Chromosome	3
Cytoband	q24
Chromosome location (bp)	148865256 - 148897196
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163751 (version 83.38)
Entrez gene	1359
UniProt	P15088 (UniProt - Evidence at protein level)
neXtProt	NX_P15088
Antibodypedia	CPA3 antibodies

PROTEIN BROWSER

CPA3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPA3-001 ENSP00000296046 ENST00000296046	P15088 [Direct mapping] Mast cell carboxypeptidase A Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002002 [regulation of angiotensin levels in blood] GO:0002003 [angiotensin maturation] GO:0002230 [positive regulation of defense response to virus by host] GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0030133 [transport vesicle] GO:0030141 [secretory granule] GO:0044267 [cellular protein metabolic process] Show all	417 aa 48.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.