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Most cancer cells displayed moderate nuclear positivity. A few colorectal cancers were strongly stained. Several lymphomas were weakly stained or negative.
Moderate to strong cytoplasmic and membranous positivity was observed in endometrial cancers. Melanomas, thyroid and renal cancers displayed moderate cytoplasmic staining. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
RYK (HGNC Symbol)
Synonyms
D3S3195, JTK5, JTK5A, RYK1
Description
Receptor-like tyrosine kinase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
