Cell atlas - KIAA1143 - The Human Protein Atlas

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KIAA1143

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Nucleus

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KIAA1143
Gene description	KIAA1143
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytokinetic bridge.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by correlation analysis, biological definition and custom assay

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA061799
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytokinetic bridge.

Main location

Nucleus (approved)

Additional location

Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061799	RH-30	Nucleus
	HPA061799	SiHa	Nucleus
	HPA061799	SiHa	Cytokinetic bridge	Intensity	Intensity
	HPA061799	U-2 OS	Nucleus	Intensity	Intensity

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA061799	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. KIAA1143 is mostly expressed during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to correlation analysis, biological definition and custom assay
Intensity variation	Cytokinetic bridge, Nucleus
HPA061799

GENE INFORMATION
Gene name	KIAA1143
Synonyms
Description	KIAA1143 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	44737661 - 44761662
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163807 (version 83.38)
Entrez gene	57456
UniProt	Q96AT1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AT1
Antibodypedia	KIAA1143 antibodies

PROTEIN BROWSER

KIAA1143-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIAA1143-001 ENSP00000296121 ENST00000296121	Q96AT1 [Direct mapping] Uncharacterized protein KIAA1143 A0A024R2T2 [Target identity:100%; Query identity:100%] KIAA1143, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	154 aa 17.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.