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Cancer tissues showed weak to moderate cytoplasmic staining. Occasional cases of endometrial cancers showed strong positivity. Several cases of gliomas, lymphomas, lung, renal and liver cancers along with majority of stroma were negative.
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Q9NQ48 [Direct mapping] Leucine zipper transcription factor-like protein 1
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Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0032403 [protein complex binding] GO:0042802 [identical protein binding] GO:1903565 [negative regulation of protein localization to cilium] GO:1903568 [negative regulation of protein localization to ciliary membrane]
Q9NQ48 [Direct mapping] Leucine zipper transcription factor-like protein 1
Show all
Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0032403 [protein complex binding] GO:0042802 [identical protein binding] GO:1903565 [negative regulation of protein localization to cilium] GO:1903568 [negative regulation of protein localization to ciliary membrane]
Q9NQ48 [Direct mapping] Leucine zipper transcription factor-like protein 1
Show all
Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0032403 [protein complex binding] GO:0042802 [identical protein binding] GO:1903565 [negative regulation of protein localization to cilium] GO:1903568 [negative regulation of protein localization to ciliary membrane]
