Cell atlas - FYCO1 - The Human Protein Atlas

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FYCO1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	FYCO1
Gene description	FYVE and coiled-coil domain containing 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (validated)
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA035526 , HPA057966
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ASSAYS

RNA expression

Human cells

GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA035526	A-431	Vesicles
HPA035526	RT4	Golgi apparatus
HPA035526	RT4	Vesicles
HPA035526	U-2 OS	Vesicles
HPA057966	RT4	Vesicles
HPA057966	U-2 OS	Vesicles
HPA057966	U-251 MG	Vesicles

GFP

Antibody

HPA035526

Validation

C-terminal tag
BAC cell line: 5295
Validated: Antibody staining overlaps with GFP tagged protein

N-terminal tag
BAC cell line: 5296
Validated: Antibody staining overlaps with GFP tagged protein

Antibody

HPA057966

Validation

C-terminal tag
BAC cell line: 5295
Validated: Antibody staining overlaps with GFP tagged protein

N-terminal tag
BAC cell line: 5296
Validated: Antibody staining overlaps with GFP tagged protein but show additional locations


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
HPA035526	HeLa	5295	C-terminal	Vesicles	Vesicles
HPA035526	HeLa	5296	N-terminal	Vesicles	Vesicles
HPA035526	HeLa	Normal	-	Vesicles	-
HPA057966	HeLa	5295	C-terminal	Vesicles	Vesicles
HPA057966	HeLa	5296	N-terminal	Nucleus, Vesicles	Vesicles
HPA057966	HeLa	Normal	-	No staining	-

GENE INFORMATION
Gene name	FYCO1 (HGNC Symbol)
Synonyms	FLJ13335, ZFYVE7
Description	FYVE and coiled-coil domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	45917899 - 45995824
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163820 (version 83.38)
Entrez gene	79443
UniProt	Q9BQS8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQS8
Antibodypedia	FYCO1 antibodies

PROTEIN BROWSER

FYCO1-001	FYCO1-003	FYCO1-006	FYCO1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FYCO1-001 ENSP00000296137 ENST00000296137	Q9BQS8 [Direct mapping] FYVE and coiled-coil domain-containing protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005776 [autophagosome] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0046872 [metal ion binding] GO:0072383 [plus-end-directed vesicle transport along microtubule] Show all	1478 aa 167 kDa	No	0
FYCO1-003 ENSP00000388136 ENST00000433878	H7BZ74 [Direct mapping] FYVE and coiled-coil domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	267 aa 28.7 kDa	No	0
FYCO1-006 ENSP00000398517 ENST00000438446	C9J2W6 [Direct mapping] FYVE and coiled-coil domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	149 aa 16.7 kDa	No	0
FYCO1-201 ENSP00000441178 ENST00000535325	Q9BQS8 [Direct mapping] FYVE and coiled-coil domain-containing protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005776 [autophagosome] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031410 [cytoplasmic vesicle] GO:0046872 [metal ion binding] GO:0072383 [plus-end-directed vesicle transport along microtubule] Show all	1498 aa 168.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.