Tissue expression of LIPH - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LIPH
Gene description	Lipase, member H
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (stomach, rectum)
GTEx:	Tissue enhanced (stomach)
FANTOM5:	Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues with additional plasma positivity.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA049079
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (stomach, rectum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (stomach)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION
Gene name	LIPH (HGNC Symbol)
Synonyms	LPDLR, mPA-PLA1, mPA-PLA1alpha, PLA1B
Description	Lipase, member H (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.2
Chromosome location (bp)	185506262 - 185552613
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163898 (version 83.38)
Entrez gene	200879
UniProt	Q8WWY8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWY8
Antibodypedia	LIPH antibodies

PROTEIN BROWSER

LIPH-001	LIPH-002	LIPH-005	LIPH-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIPH-001 ENSP00000296252 ENST00000296252	Q8WWY8 [Direct mapping] Lipase member H Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0004620 [phospholipase activity] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0008201 [heparin binding] GO:0016042 [lipid catabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	451 aa 50.9 kDa	Yes	0
LIPH-002 ENSP00000396384 ENST00000424591	A2IBA6 [Direct mapping] Lipase member H; Mutant lipase H Show all	Phobius predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	417 aa 47.2 kDa	Yes	0
LIPH-005 ENSP00000408218 ENST00000452897	H7C2X1 [Direct mapping] Lipase member H Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	86 aa 9.6 kDa	No	0
LIPH-006 ENSP00000390228 ENST00000435679	H7BZL3 [Direct mapping] Lipase member H Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	73 aa 8.1 kDa	No	0