Cell atlas - RPN1 - The Human Protein Atlas

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RPN1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	RPN1
Gene description	Ribophorin I
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA026828 , HPA051520
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026828	A-431	Endoplasmic reticulum
	HPA026828	U-2 OS	Cytosol
	HPA051520	A-431	Endoplasmic reticulum
	HPA051520	U-2 OS	Endoplasmic reticulum
	HPA051520	U-251 MG	Cytosol

GENE INFORMATION
Gene name	RPN1 (HGNC Symbol)
Synonyms	OST1
Description	Ribophorin I (HGNC Symbol)
Entrez gene summary	This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q21.3
Chromosome location (bp)	128619970 - 128681075
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163902 (version 83.38)
Entrez gene	6184
UniProt	P04843 (UniProt - Evidence at protein level)
neXtProt	NX_P04843
Antibodypedia	RPN1 antibodies

PROTEIN BROWSER

RPN1-001	RPN1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPN1-001 ENSP00000296255 ENST00000296255	P04843 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005791 [rough endoplasmic reticulum] GO:0006412 [translation] GO:0006464 [cellular protein modification process] GO:0006486 [protein glycosylation] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0008250 [oligosaccharyltransferase complex] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0042470 [melanosome] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] Show all	607 aa 68.6 kDa	Yes	1
RPN1-002 ENSP00000417529 ENST00000497289	B7Z4L4 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0016021 [integral component of membrane] Show all	435 aa 49.9 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.