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HEYL

GENERAL INFORMATION

Gene name

 HEYL

Gene description

 Hes-related family bHLH transcription factor with YRPW motif-like

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HEYL (HGNC Symbol)

Synonyms

 bHLHb33, HESR3, HEY3

Description

 Hes-related family bHLH transcription factor with YRPW motif-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 39624153 - 39639945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000163909 (version 83.38)

Entrez gene

 26508

UniProt

 Q9NQ87 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQ87

Antibodypedia

 HEYL antibodies

PROTEIN BROWSER
HEYL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HEYL-001
ENSP00000361943
ENST00000372852
Q9NQ87 [Direct mapping]
Hairy/enhancer-of-split related with YRPW motif-like protein
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0000988 [transcription factor activity, protein binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003151 [outflow tract morphogenesis]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003208 [cardiac ventricle morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0010629 [negative regulation of gene expression]
GO:0014031 [mesenchymal cell development]
GO:0032835 [glomerulus development]
GO:0035914 [skeletal muscle cell differentiation]
GO:0035939 [microsatellite binding]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0050683 [AF-1 domain binding]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060412 [ventricular septum morphogenesis]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0071773 [cellular response to BMP stimulus]
GO:0072014 [proximal tubule development]
GO:2000824 [negative regulation of androgen receptor activity]
Show all
 328 aa
35.1 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.