Cell atlas - GNL3 - The Human Protein Atlas

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GNL3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoli

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GNL3
Gene description	Guanine nucleotide binding protein-like 3 (nucleolar)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (validated)
Additional location	In addition localized to the Nuclear bodies (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB020770 , HPA036743
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nuclear bodies.

Main location

Nucleoli (validated)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
CAB020770	A-431	Nucleoli
CAB020770	U-2 OS	Nucleoli
CAB020770	U-251 MG	Nucleoli
HPA036743	A-431	Nucleoli
HPA036743	A-431	Nuclear bodies	Intensity
HPA036743	U-2 OS	Nucleoli
HPA036743	U-2 OS	Nuclear bodies	Intensity	Intensity
HPA036743	U-251 MG	Nucleoli
HPA036743	U-251 MG	Nuclear bodies	Intensity

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA036743	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. GNL3 is mostly expressed during G1.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Nuclear bodies

GENE INFORMATION
Gene name	GNL3 (HGNC Symbol)
Synonyms	C77032, E2IG3, MGC800, NS
Description	Guanine nucleotide binding protein-like 3 (nucleolar) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	52681156 - 52694492
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163938 (version 83.38)
Entrez gene	26354
UniProt	Q9BVP2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVP2
Antibodypedia	GNL3 antibodies

PROTEIN BROWSER

GNL3-001	GNL3-002	GNL3-008	GNL3-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNL3-001 ENSP00000395772 ENST00000418458	Q9BVP2 [Direct mapping] Guanine nucleotide-binding protein-like 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0042127 [regulation of cell proliferation] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter] Show all	549 aa 62 kDa	No	0
GNL3-002 ENSP00000378278 ENST00000394799	Q9BVP2 [Direct mapping] Guanine nucleotide-binding protein-like 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0016020 [membrane] GO:0042127 [regulation of cell proliferation] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter] Show all	537 aa 60.5 kDa	No	0
GNL3-008 ENSP00000419895 ENST00000474423	C9JYH9 [Direct mapping] Guanine nucleotide-binding protein-like 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005730 [nucleolus] GO:0042254 [ribosome biogenesis] Show all	96 aa 11.7 kDa	No	0
GNL3-011 ENSP00000419734 ENST00000479230	C9JZT7 [Direct mapping] Guanine nucleotide-binding protein-like 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005730 [nucleolus] GO:0042254 [ribosome biogenesis] Show all	135 aa 16 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.