Cell atlas - SLBP - The Human Protein Atlas

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SLBP

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SLBP
Gene description	Stem-loop binding protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Additional location	In addition localized to the Nucleoli (supported), Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA061670
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.

Main location

Nucleus (supported)

Additional location

Nucleoli (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061670	RH-30	Nucleus	Spatial
			Nucleoli	Spatial
			Cytosol	Spatial
	HPA061670	U-2 OS	Nucleus	Spatial	Spatial
			Nucleoli	Spatial	Spatial
			Cytosol	Spatial	Spatial
	HPA061670	U-251 MG	Nucleus	Spatial
	HPA061670	U-251 MG	Nucleoli	Spatial

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA061670	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. SLBP is mostly expressed during G1, and at the G1/S checkpoint.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Spatial variation	Cytosol, Nucleoli, Nucleus

GENE INFORMATION
Gene name	SLBP (HGNC Symbol)
Synonyms	HBP
Description	Stem-loop binding protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	1692800 - 1712555
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163950 (version 83.38)
Entrez gene	7884
UniProt	Q14493 (UniProt - Evidence at protein level)
neXtProt	NX_Q14493
Antibodypedia	SLBP antibodies

PROTEIN BROWSER

SLBP-001	SLBP-002	SLBP-003	SLBP-004	SLBP-006	SLBP-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLBP-001 ENSP00000417686 ENST00000489418	Q14493 [Direct mapping] Histone RNA hairpin-binding protein Q53XR2 [Target identity:100%; Query identity:100%] Stem-loop (Histone) binding protein; Stem-loop (Histone) binding protein, isoform CRA_b; cDNA, FLJ96722, Homo sapiens stem-loop (histone) binding protein (SLBP), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006398 [histone mRNA 3'-end processing] GO:0006406 [mRNA export from nucleus] GO:0008334 [histone mRNA metabolic process] GO:0010467 [gene expression] GO:0030529 [ribonucleoprotein complex] GO:0031124 [mRNA 3'-end processing] GO:0033260 [nuclear DNA replication] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] GO:0071204 [histone pre-mRNA 3'end processing complex] GO:0071207 [histone pre-mRNA stem-loop binding] GO:0071208 [histone pre-mRNA DCP binding] Show all	270 aa 31.3 kDa	No	0
SLBP-002 ENSP00000406322 ENST00000429429	Q14493 [Direct mapping] Histone RNA hairpin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006369 [termination of RNA polymerase II transcription] GO:0006398 [histone mRNA 3'-end processing] GO:0006406 [mRNA export from nucleus] GO:0008334 [histone mRNA metabolic process] GO:0010467 [gene expression] GO:0030529 [ribonucleoprotein complex] GO:0031124 [mRNA 3'-end processing] GO:0033260 [nuclear DNA replication] GO:0044822 [poly(A) RNA binding] GO:0051028 [mRNA transport] GO:0071204 [histone pre-mRNA 3'end processing complex] GO:0071207 [histone pre-mRNA stem-loop binding] GO:0071208 [histone pre-mRNA DCP binding] Show all	231 aa 26.7 kDa	No	0
SLBP-003 ENSP00000418658 ENST00000488267	E7EUV9 [Direct mapping] Histone RNA hairpin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003729 [mRNA binding] Show all	235 aa 27.3 kDa	No	0
SLBP-004 ENSP00000316490 ENST00000318386	F8W8D3 [Direct mapping] Histone RNA hairpin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003729 [mRNA binding] Show all	277 aa 32.1 kDa	No	0
SLBP-006 ENSP00000417359 ENST00000480936	H7C4H8 [Direct mapping] Histone RNA hairpin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003729 [mRNA binding] Show all	186 aa 21.2 kDa	No	0
SLBP-007 ENSP00000426891 ENST00000483348	H0YAE8 [Direct mapping] Histone RNA hairpin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003729 [mRNA binding] Show all	225 aa 26.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.