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A majority of colorectal and pancreatic carcinomas displayed strong membranous staining while several malignant melanomas showed strong cytoplasmic and membranous positivity. Malignant cells in general showed weak to moderate cytoplasmic staining. Malignant lymphomas were negative.
GENE INFORMATION
Gene name
MFI2 (HGNC Symbol)
Synonyms
CD228, FLJ38863, MAP97, MGC4856, MTf, MTF1
Description
Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
P08582 [Direct mapping] Melanotransferrin Q53XS6 [Target identity:100%; Query identity:100%] Antigen p97 (Melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; Antigen p97 (Melanoma associated) identified by monoclonal antibodies 133.2 and 96.5, isoform CRA_b; Melanoma-associated antigen p97, isoform 2
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CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0009986 [cell surface] GO:0010756 [positive regulation of plasminogen activation] GO:0046658 [anchored component of plasma membrane] GO:0055072 [iron ion homeostasis] GO:0070062 [extracellular exosome] GO:0090091 [positive regulation of extracellular matrix disassembly] GO:0097286 [iron ion import] GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
