Tissue expression of CLDN19 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CLDN19
Gene description	Claudin 19
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (kidney, placenta)
GTEx:	Tissue enriched (kidney)
FANTOM5:	Group enriched (retina, kidney, placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (retina, kidney, placenta)

GENE INFORMATION
Gene name	CLDN19
Synonyms
Description	Claudin 19 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	42733093 - 42740254
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164007 (version 83.38)
Entrez gene	149461
UniProt	Q8N6F1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N6F1
Antibodypedia	CLDN19 antibodies

PROTEIN BROWSER

CLDN19-001	CLDN19-002	CLDN19-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN19-001 ENSP00000296387 ENST00000296387	Q8N6F1 [Direct mapping] Claudin-19 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005198 [structural molecule activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005923 [bicellular tight junction] GO:0007601 [visual perception] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0019227 [neuronal action potential propagation] GO:0030054 [cell junction] GO:0042802 [identical protein binding] GO:0043296 [apical junction complex] GO:0043297 [apical junction assembly] GO:0050896 [response to stimulus] Show all	224 aa 23.2 kDa	No	4
CLDN19-002 ENSP00000361617 ENST00000372539	Q8N6F1 [Direct mapping] Claudin-19 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005198 [structural molecule activity] GO:0005923 [bicellular tight junction] GO:0007601 [visual perception] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0043296 [apical junction complex] GO:0050896 [response to stimulus] Show all	211 aa 22.1 kDa	No	4
CLDN19-201 ENSP00000443229 ENST00000539749	Q8N6F1 [Direct mapping] Claudin-19 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005198 [structural molecule activity] GO:0005923 [bicellular tight junction] GO:0007601 [visual perception] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0043296 [apical junction complex] GO:0050896 [response to stimulus] Show all	218 aa 22.7 kDa	No	3