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Cancer cells displayed moderate cytoplasmic and membranous positivity. Colorectal cancers were predominantly strongly stained as well as several cases of testis, gastric and liver cancers.
GENE INFORMATION
Gene name
SGMS2 (HGNC Symbol)
Synonyms
MGC26963, SMS2
Description
Sphingomyelin synthase 2 (HGNC Symbol)
Entrez gene summary
Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008]
