Expression of H2AFZ in cancer - Summary

CANCER ATLAS

Gene description

H2A histone family, member Z

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA057236	CAB022549

GENE INFORMATION
Gene name	H2AFZ (HGNC Symbol)
Synonyms	H2A.Z, H2AZ
Description	H2A histone family, member Z (HGNC Symbol)
Entrez gene summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	99948086 - 99950388
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164032 (version 83.38)
Entrez gene	3015
UniProt	P0C0S5 (UniProt - Evidence at protein level)
neXtProt	NX_P0C0S5
Antibodypedia	H2AFZ antibodies

PROTEIN BROWSER

H2AFZ-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
H2AFZ-001 ENSP00000296417 ENST00000296417	P0C0S5 [Direct mapping] Histone H2A.Z Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0000786 [nucleosome] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005719 [nuclear euchromatin] GO:0005720 [nuclear heterochromatin] GO:0006325 [chromatin organization] GO:0006342 [chromatin silencing] GO:0031490 [chromatin DNA binding] GO:0031492 [nucleosomal DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] GO:0071392 [cellular response to estradiol stimulus] Show all	128 aa 13.6 kDa	No	0