Tissue expression of CDC25A - Summary - The Human Protein Atlas

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CDC25A

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CDC25A
Gene description	Cell division cycle 25A
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA005855
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION
Gene name	CDC25A
Synonyms
Description	Cell division cycle 25A (HGNC Symbol)
Entrez gene summary	CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48157146 - 48188402
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164045 (version 83.38)
Entrez gene	993
UniProt	P30304 (UniProt - Evidence at protein level)
neXtProt	NX_P30304
Antibodypedia	CDC25A antibodies

PROTEIN BROWSER

CDC25A-001	CDC25A-002	CDC25A-003	CDC25A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDC25A-001 ENSP00000303706 ENST00000302506	P30304 [Direct mapping] M-phase inducer phosphatase 1 A0A024R2S4 [Target identity:100%; Query identity:100%] Cell division cycle 25A, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000087 [mitotic M phase] GO:0000278 [mitotic cell cycle] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006470 [protein dephosphorylation] GO:0007067 [mitotic nuclear division] GO:0008283 [cell proliferation] GO:0009314 [response to radiation] GO:0019901 [protein kinase binding] GO:0034644 [cellular response to UV] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	524 aa 59.1 kDa	No	0
CDC25A-002 ENSP00000343166 ENST00000351231	P30304 [Direct mapping] M-phase inducer phosphatase 1 A0A024R2R6 [Target identity:100%; Query identity:100%] Cell division cycle 25A, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000087 [mitotic M phase] GO:0000278 [mitotic cell cycle] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006260 [DNA replication] GO:0006470 [protein dephosphorylation] GO:0007067 [mitotic nuclear division] GO:0008283 [cell proliferation] GO:0009314 [response to radiation] GO:0019901 [protein kinase binding] GO:0034644 [cellular response to UV] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	484 aa 54.6 kDa	No	0
CDC25A-003 ENSP00000404285 ENST00000437972	C9JH94 [Direct mapping] M-phase inducer phosphatase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0000087 [mitotic M phase] GO:0004725 [protein tyrosine phosphatase activity] GO:0005622 [intracellular] GO:0006470 [protein dephosphorylation] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	143 aa 15.5 kDa	No	0
CDC25A-004 ENSP00000416483 ENST00000443342	C9JFR5 [Direct mapping] M-phase inducer phosphatase 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0000087 [mitotic M phase] GO:0004725 [protein tyrosine phosphatase activity] GO:0005622 [intracellular] GO:0006470 [protein dephosphorylation] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	252 aa 27.6 kDa	No	0

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The Project

The Human Protein Atlas

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by the Knut & Alice Wallenberg foundation.