Expression of SHISA5 in cancer - Summary

CANCER ATLAS

Gene description

Shisa family member 5

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042295

GENE INFORMATION
Gene name	SHISA5 (HGNC Symbol)
Synonyms	hShisa5, SCOTIN
Description	Shisa family member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the shisa family. The encoded protein is localized to the endoplasmic reticulum, and together with p53 induces apoptosis in a caspase-dependent manner. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	48467798 - 48504826
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164054 (version 83.38)
Entrez gene	51246
UniProt	Q8N114 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N114
Antibodypedia	SHISA5 antibodies

PROTEIN BROWSER

SHISA5-001	SHISA5-002	SHISA5-007	SHISA5-009	SHISA5-012	SHISA5-017	SHISA5-201	SHISA5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SHISA5-001 ENSP00000296444 ENST00000296444	Q8N114 [Direct mapping] Protein shisa-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050699 [WW domain binding] GO:0070062 [extracellular exosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	240 aa 25.6 kDa	Yes	1
SHISA5-002 ENSP00000390388 ENST00000426002	Q8N114 [Direct mapping] Protein shisa-5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050699 [WW domain binding] GO:0070062 [extracellular exosome] Show all	137 aa 14.5 kDa	No	0
SHISA5-007 ENSP00000408223 ENST00000442747	Q8N114 [Direct mapping] Protein shisa-5 A0A024R2S8 [Target identity:100%; Query identity:100%] Scotin, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050699 [WW domain binding] GO:0070062 [extracellular exosome] Show all	209 aa 22.4 kDa	No	1
SHISA5-009 ENSP00000395373 ENST00000443308	Q8N114 [Direct mapping] Protein shisa-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050699 [WW domain binding] GO:0070062 [extracellular exosome] Show all	233 aa 24.9 kDa	Yes	1
SHISA5-012 ENSP00000407957 ENST00000444115	Q8N114 [Direct mapping] Protein shisa-5 A0A024R2S8 [Target identity:100%; Query identity:100%] Scotin, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050699 [WW domain binding] GO:0070062 [extracellular exosome] Show all	209 aa 22.4 kDa	No	1
SHISA5-017 ENSP00000412509 ENST00000417841	C9IZ46 [Direct mapping] Protein shisa-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	112 aa 12.2 kDa	No	1
SHISA5-201 ENSP00000482723 ENST00000612611	A0A087WZK8 [Direct mapping] Protein shisa-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		170 aa 19.1 kDa	No	1
SHISA5-202 ENSP00000484992 ENST00000619810	Q8N114 [Direct mapping] Protein shisa-5 A0A024R2S8 [Target identity:100%; Query identity:100%] Scotin, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0050699 [WW domain binding] GO:0070062 [extracellular exosome] Show all	209 aa 22.4 kDa	No	1