Expression of BSN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Bassoon presynaptic cytomatrix protein

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034757

GENE INFORMATION
Gene name	BSN (HGNC Symbol)
Synonyms	ZNF231
Description	Bassoon presynaptic cytomatrix protein (HGNC Symbol)
Entrez gene summary	Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49554489 - 49671545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164061 (version 83.38)
Entrez gene	8927
UniProt	Q9UPA5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UPA5
Antibodypedia	BSN antibodies

PROTEIN BROWSER

BSN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BSN-001 ENSP00000296452 ENST00000296452	Q9UPA5 [Direct mapping] Protein bassoon Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005802 [trans-Golgi network] GO:0007268 [synaptic transmission] GO:0007416 [synapse assembly] GO:0009986 [cell surface] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0043025 [neuronal cell body] GO:0044306 [neuron projection terminus] GO:0045202 [synapse] GO:0046872 [metal ion binding] GO:0048786 [presynaptic active zone] GO:0048788 [cytoskeleton of presynaptic active zone] GO:0060076 [excitatory synapse] GO:0060077 [inhibitory synapse] GO:0097470 [ribbon synapse] GO:0097481 [neuronal postsynaptic density] Show all	3926 aa 416.5 kDa	No	0