Cell atlas - MFSD8 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MFSD8

TISSUE

premium

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MFSD8
Gene description	Major facilitator superfamily domain containing 8
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA044802
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (supported), Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044802	A-431	Nucleoplasm
	HPA044802	A-431	Vesicles
	HPA044802	U-2 OS	Nucleoplasm
	HPA044802	U-2 OS	Vesicles
	HPA044802	U-251 MG	Nucleoplasm
	HPA044802	U-251 MG	Vesicles

GENE INFORMATION
Gene name	MFSD8 (HGNC Symbol)
Synonyms	CLN7, MGC33302
Description	Major facilitator superfamily domain containing 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]
Chromosome	4
Cytoband	q28.2
Chromosome location (bp)	127917805 - 127965995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164073 (version 83.38)
Entrez gene	256471
UniProt	Q8NHS3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NHS3
Antibodypedia	MFSD8 antibodies

PROTEIN BROWSER

MFSD8-001	MFSD8-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFSD8-001 ENSP00000296468 ENST00000296468	Q8NHS3 [Direct mapping] Major facilitator superfamily domain-containing protein 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0007040 [lysosome organization] GO:0016021 [integral component of membrane] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	518 aa 57.6 kDa	No	>9
MFSD8-003 ENSP00000425000 ENST00000513559	E7ERQ4 [Direct mapping] Major facilitator superfamily domain-containing protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	473 aa 52.3 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.