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DUSP7

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GENERAL INFORMATION

Gene name

 DUSP7

Gene description

 Dual specificity phosphatase 7

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DUSP7 (HGNC Symbol)

Synonyms

 MKP-X, PYST2

Description

 Dual specificity phosphatase 7 (HGNC Symbol)

Entrez gene summary

 Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 52048919 - 52056550

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164086 (version 83.38)

Entrez gene

 1849

UniProt

 Q16829 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16829

Antibodypedia

 DUSP7 antibodies

PROTEIN BROWSER
DUSP7-001
DUSP7-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP7-001
ENSP00000417183
ENST00000495880
Q16829 [Direct mapping]
Dual specificity protein phosphatase 7
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000188 [inactivation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
Show all
 419 aa
45 kDa 		No 0
DUSP7-002
ENSP00000418566
ENST00000469623
H7C4Z0 [Direct mapping]
Dual-specificity protein phosphatase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000188 [inactivation of MAPK activity]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
Show all
 275 aa
29.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.